What Is Acute Lymphocytic Leukemia (ALL)?

Acute lymphocytic leukemia (ALL), also called acute lymphoblastic leukemia, is a cancer that starts from white blood cells called lymphocytes in the bone marrow (the soft inner part of the bones, where new blood cells are made).
In most cases, the leukemia invades the blood fairly quickly. It can then spread to other parts of the body, including the lymph nodes, liver, spleen, central nervous system (brain and spinal cord), and testicles (in males). Other types of cancer that start in these organs and then spread to the bone marrow are not leukemia.
The term "acute" means that the leukemia can progress quickly, and if not treated, would probably be fatal in a few months. "Lymphocytic" or "lymphoblastic" means it develops from cells called lymphocytes or lymphoblasts. This is different from acute myeloid leukemia (AML), which develops in other blood cell types found in the bone marrow. For more information on AML, see our document, Leukemia--Acute Myeloid.
Other types of cancer that start in lymphocytes are known as lymphomas (non-Hodgkin lymphoma or Hodgkin disease). The main difference between these types of cancers is that ALL starts in the bone marrow and may spread to other places, while lymphomas start in lymph nodes or other organs and then may spread to the bone marrow. Sometimes cancerous lymphocytes are found in both the bone marrow and lymph nodes when the cancer is first diagnosed, which can make it hard to tell if the cancer is a leukemia or a lymphoma. If more than 25% of the bone marrow is replaced by cancerous lymphocytes, the disease is usually considered to be a leukemia. The size of lymph nodes is also important. The bigger they are, the more likely the disease is a lymphoma. For more information on lymphomas, see our documents, Non-Hodgkin Lymphoma and Hodgkin Disease.
Normal bone marrow, blood, and lymphoid tissue
In order to understand the different types of leukemia, it helps to know about the blood and lymph systems.
Bone marrow
Bone marrow is the soft inner part of some bones, such as the skull, shoulder blades, ribs, pelvis, and backbones. The bone marrow is made up of a small number of blood stem cells, more mature blood-forming cells, fat cells, and supporting tissues that help cells grow.
Blood stem cells go through a series of changes to make new blood cells. During this process, the cells develop into either lymphocytes (a kind of white blood cell) or other blood-forming cells. The blood-forming cells can develop into 1 of the 3 main types of blood cell components:
  • red blood cells
  • white blood cells (other than lymphocytes)
  • platelets
Red blood cells
Red blood cells carry oxygen from the lungs to all other tissues in the body, and take carbon dioxide back to the lungs to be removed. Anemia (having too few red blood cells in the body) typically causes a person to feel tired, weak, and short of breath because the body tissues are not getting enough oxygen.
Platelets
Platelets are actually cell fragments made by a type of bone marrow cell called the megakaryocyte. Platelets are important in plugging up holes in blood vessels caused by cuts or bruises. A shortage of platelets is called thrombocytopenia. A person with thrombocytopenia may bleed and bruise easily.
White blood cells
White blood cells help the body fight infections. Lymphocytes are one type of white blood cell. The other types of white blood cells are granulocytes (neutrophils, basophils, and eosinophils) and monocytes.
Lymphocytes: These are the main cells that make up lymphoid tissue, a major part of the immune system. Lymphoid tissue is found in lymph nodes, the thymus gland, the spleen, the tonsils and adenoids, and is scattered throughout the digestive and respiratory systems and the bone marrow.
Lymphocytes develop from cells called lymphoblasts to become mature, infection-fighting cells. The 2 main types of lymphocytes are B lymphocytes (B cells) and T lymphocytes (T cells).
  • B lymphocytes: B lymphocytes protect the body from invading germs by developing (maturing) into plasma cells, which make proteins called antibodies. The antibodies attach to the germs (bacteria, viruses, and fungi), which helps other white blood cells called granulocytes to recognize and destroy them.
  • T lymphocytes: T lymphocytes can recognize cells infected by viruses and directly destroy these cells.
Granulocytes: These are white blood cells that have granules in them, which are spots that can be seen under the microscope. These granules contain enzymes and other substances that can destroy germs, such as bacteria. The 3 types of granulocytes -- neutrophils, basophils, and eosinophils -- are distinguished by the size and color of their granules. Granulocytes develop from blood-forming cells called myeloblasts to become mature, infection-fighting cells.
Monocytes: These white blood cells, which are related to granulocytes, also help protect the body against bacteria. They start in the bone marrow as blood-forming monoblasts and develop into mature monocytes. After circulating in the bloodstream for about a day, monocytes enter body tissues to become macrophages, which can destroy some germs by surrounding and digesting them. Macrophages also help lymphocytes recognize germs and start making antibodies to fight them.
Any of the blood-forming or lymphoid cells from the bone marrow can turn into a leukemia cell. Once this change takes place, the leukemia cells fail to go through their normal process of maturing. Leukemia cells may reproduce quickly, but in most cases they don't die when they should. They survive and build up in the bone marrow. Over time, these cells spill into the bloodstream and spread to other organs, where they can keep other cells in the body from functioning normally.
Types of leukemia
Not all leukemias are the same. Leukemias are divided into 4 main types. Knowing the specific type of leukemia helps doctors better predict each patient's prognosis (outlook) and select the best treatment.
Acute leukemia versus chronic leukemia
The first factor in classifying a patient's leukemia is whether most of the abnormal cells are mature (look like normal white blood cells) or immature (look more like stem cells).
Acute leukemia: In acute leukemia, the bone marrow cells cannot mature properly. Immature leukemia cells continue to reproduce and build up. Without treatment, most patients with acute leukemia would live only a few months. Some types of acute leukemia respond well to treatment, and many patients can be cured. Other types of acute leukemia have a less favorable outlook.
Chronic leukemia: In chronic leukemia, the cells can mature partly but not completely. These cells may look fairly normal, but they are not. They generally do not fight infection as well as do normal white blood cells. And they survive longer, build up, and crowd out normal cells. Chronic leukemias tend to progress over a longer period of time, and most patients can live for many years. But chronic leukemias are generally harder to cure than acute leukemias.
Myeloid leukemia versus lymphocytic leukemia
The second factor in classifying leukemia is the type of bone marrow cells that are affected.
Myeloid leukemia: Leukemias that start in early forms of myeloid cells -- white blood cells (other than lymphocytes), red blood cells, or platelet-making cells (megakaryocytes) -- are myeloid leukemias (also known as myelocytic, myelogenous, or non-lymphocytic leukemias).
Lymphocytic leukemia: If the cancer starts in early forms of lymphocytes, it is called lymphocytic leukemia (also known as lymphoid or lymphoblastic leukemia). Lymphomas are also cancers that start in lymphocytes. Lymphocytic leukemias develop from cells in the bone marrow, but lymphomas develop from cells in lymph nodes or other organs.
Leukemias can be divided into 4 main types based on whether they are acute or chronic, and whether they are myeloid or lymphocytic. The 4 main types are:
  • acute myeloid (or myelogenous) leukemia (AML)
  • chronic myeloid (or myelogenous) leukemia (CML)
  • acute lymphocytic (or lymphoblastic) leukemia (ALL)
  • chronic lymphocytic leukemia (CLL)
ALL is the most common of the 4 major types of leukemia among children, but it is actually the least common type among adults.
The rest of this document focuses on acute lymphocytic leukemia (ALL) in adults. For information on ALL in children, please see our document, Childhood Leukemias. Chronic leukemias and acute myeloid leukemia of adults are discussed in other American Cancer Society documents.

What Is Cancer?

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Cancer begins when cells in a part of the body start to grow out of control. There are many kinds of cancer, but they all start because of out-of-control growth of abnormal cells.
How a normal cell becomes cancer
Normal body cells grow, divide, and die in an orderly fashion. During the early years of a person's life, normal cells divide faster to allow the person to grow. After the person becomes an adult, most cells divide only to replace worn-out or dying cells or to repair injuries.
Because cancer cells continue to grow and divide, they are different from normal cells. Instead of dying, cancer cells outlive normal cells and keep forming new abnormal cells. Another difference between cancer cells and normal cells is that cancer cells can invade (grow into) other tissues. Being able to grow out of control and to invade other tissues makes a cell a cancer cell.
Cells become cancer cells because of damage to DNA. DNA is in every cell and directs all its actions. Most of the time, when DNA gets damaged the cell can fix it. If the cell can’t repair the damage, the cell dies. In cancer cells the damaged DNA is not repaired, but the cell doesn’t die like it should. Instead, this cell goes on making new cells even though the body does not need them. These new cells will all have the same DNA damage as the first cell does.
People can inherit damaged DNA, but most of the time DNA damage is caused by something we are exposed to in our environment. Sometimes the cause of the DNA damage is something obvious, like cigarette smoking. But many times no clear cause is found.
A cancer cell has many mistakes in its DNA -- having damage in just one spot does not cause cancer. Even when someone inherits damaged DNA, more mistakes in their DNA are needed before a cancer will develop. Staying away from things that are known to damage DNA (like smoking) as a part of a healthy life style lowers the chance that more DNA damage will take place. This can reduce the risk of cancer -- even in people who have an inherited tendency to get cancer.
How cancers grow and spread
In most cases the cancer cells form a tumor. Some cancers, like leukemia, do not form tumors. Instead, these cancer cells involve the blood and blood-forming organs and circulate through other tissues where they grow. But sometimes the extra cells in these blood cancers may also form a mass of tissue called a tumor.
Cancer cells often travel to other parts of the body, where they begin to grow and replace normal tissue. This process is called metastasis. It happens when the cancer cells get into the bloodstream or lymph vessels of our body.
But no matter where a cancer may spread, it is always named for the place where it started. For example, breast cancer that has spread to the liver is still called breast cancer, not liver cancer. Prostate cancer that has spread to the bone is metastatic prostate cancer, not bone cancer.
Not all tumors are cancerous. Tumors that aren't cancer are called benign. Benign tumors can cause problems -- they can grow very large and press on healthy organs and tissues. But they cannot grow into (invade) other tissues. Because they can't invade, they also can't spread to other parts of the body (metastasize). These tumors are almost never life threatening.
How cancers differ
Different types of cancer can behave very differently. For example, lung cancer and breast cancer are very different diseases. They grow at different rates and respond to different treatments. That is why people with cancer need treatment that is aimed at their particular kind of cancer.
How common is cancer
Cancer is the second leading cause of death in the United States. Nearly half of all men and a little over one third of all women in the United States will develop cancer during their lifetimes.
Today, millions of people are living with cancer or have had cancer. The risk of developing most types of cancer can be reduced by changes in a person's lifestyle, for example, by quitting smoking and eating a better diet. Often, the sooner a cancer is found and treatment begins, the better are the chances for living for many years.
 

New Light-Emitting Biomaterial Could Improve Tumor Imaging, Study Shows

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August 10, 2009 — A new material developed at the University of Virginia – an oxygen nanosensor that couples a light-emitting dye with a biopolymer – simplifies the imaging of oxygen-deficient regions of tumors. Such tumors are associated with increased cancer aggressiveness and are particularly difficult to treat.

U.Va. Researcher Aims to Make Cancer Manageable




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News Source: Explorations
Aug. 12, 2009 — Until recently, treatment for cancer – though quite sophisticated in practice – has been limited to three basic approaches: killing cancer cells by removing them surgically, blasting them with radiation or poisoning them with chemotherapy. The goal is to destroy all malignant cells, curing the cancer and preventing remission. Even when these three approaches are used in combination and treatment is administered repeatedly, some cancer cells survive, and the disease can and does recur.

In a way, the flaw in this line of attack has been its ambition. In the last few years, a number of treatments have been approved with the more modest goal of simply holding cancer in check. They do this by blocking the cellular pathways that enable cancer cells to grow and flourish.

Tau Therapeutics, based on intellectual property patented at the University of Virginia by Timothy Macdonald, a medicinal chemist, and former faculty member Lloyd Gray, a pathologist, specializes in developing cancer-fighting drugs that control the calcium T-channel in cells – tiny transient openings in the cell membrane that allow calcium, which is necessary for cell proliferation, to enter the cell.

"If we can stop the tumor cells from dividing, we can provide a meaningful increase in lifespan," Macdonald said.

"Tau's method represents an advance over other treatments to halt the growth of cancer," says Tau's president and CEO Andrew Krouse. "That’s because all pathways for tumor cell proliferation – for tumor growth as well as for the new blood vessels needed for tumor growth – converge at the point of the calcium T-channel, CaV3.2, that Tau has patented."

Tau's vision is to block CaV3.2, thus allowing cancer to be managed as a chronic disease like diabetes or heart disease.

Tau's initial focus is to reposition existing calcium-channel blockers that have already been approved for other conditions, a tactic that can decrease the time to bring the new cancer medications to market.

For instance, it will be sponsoring a clinical trial to test the efficacy of mibefradil, a calcium-channel blocker that had been approved for the treatment of hypertension and chronic angina. Tau envisions mibefradil being used in combination with other medications to treat a wide range of cancers.

Tau's longer-term strategy involves building libraries of small molecules that could control calcium-channel processes. It has patented two libraries, synthesized and tested more than 400 compounds, and has identified several viable substances for development.

The first of these, TTL 1177 – a drug targeted at colon cancer – is undergoing laboratory testing, and Tau could file an investigational new drug application with the U.S. Food and Drug Administration within the next 18 months.

Tau's approach could have several advantages. Unlike conventional cancer treatments, Tau's medications will not destroy healthy tissue; because calcium T-channels only appear during adulthood as part of a pathological condition like cancer, T-channel blockers focus only on cancer cells. In addition, molecules in Tau's pipeline can be administered orally, an improvement over drugs like Avastin that must be injected.

Ultimately, Tau's goal is to be the world leader in producing calcium T-channel drugs for the personalized treatment of cancer.

"We envision combining early detection through diagnostic screening of the calcium T-channel, biopsies for the particular expression of the target, and the prescription of complementary drugs based on the molecules in our library," Krouse said. "In this way, we hope to treat cancer like any other chronic disease, extending both the length and quality of life of people with cancer."


— By Charlie Feigenoff

Additional Resources

More information from your American CancerSociety
We have some related information that may also be helpful to you. These materials may be ordered from our toll-free number, 1-800-227-2345.
The following books are available from the American Cancer Society. Call us at 1-800-227-2345 to ask about costs or to place your order.
National organizations and Web sites*
In addition to the American Cancer Society, other sources of patient information and support include:
Acute lymphocytic leukemia
Leukemia & Lymphoma Society
Toll-free number: 1-800-955-4572
Web site: www.lls.org
National Cancer Institute
Toll-free number: 1-800-4-CANCER (1-800-422-6237)
Web site: www.cancer.gov
Bone marrow and peripheral blood stem cell transplants
Caitlin Raymond International Registry (for unrelated bone marrow transplants)
Toll-free number: 1-800-726-2824
Web site: www.crir.org
National Bone Marrow Transplant Link (nbmtLINK)
Toll-free number: 1-800-LINK-BMT (1-800-546-5268)
Web site: www.nbmtlink.org
National Marrow Donor Program
Toll-free number: 1-800-MARROW-2 (1-800-627-7692)
Web site: www.marrow.org
*Inclusion on this list does not imply endorsement by the American Cancer Society.
No matter who you are, we can help. Contact us anytime, day or night, for information and support. Call us at 1-800-227-2345 or visit cancer.org.

New ACS Report Offers Detailed Portrait of Cancer Among Hispanics

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Hispanic Americans are less likely to die from cancer than other groups, but have higher rates of cancers related to infections (stomach, liver, and cervix) and are more likely to be diagnosed at an advanced stage of the disease when treatment may be more difficult, according to Cancer Facts & Figures for Hispanics 2009-2011, the latest edition of this American Cancer Society report.
Cancer is the second leading cause of death among Hispanics, responsible for 20% of overall deaths and 13% of deaths in children. However, for all cancers combined, cancer incidence and death rates are lower among Hispanics than among non-Hispanic whites. Incidence rates among Hispanic men declined an average of 1.3% per year from 1997 to 2006, compared to 0.8% per year among non-Hispanic men. Cancer death rates declined an average of 2.2% per year among Hispanic men and 1.2% per year among Hispanic women over the same period, compared to declines of 1.5% in men and 0.9% in women among non-Hispanic whites.
According to the report, the most common cancers among Hispanic men in 2009 are projected to be prostate (24%), colorectal (12%), and lung (10%). Among Hispanic women, the most common are breast (28%), colorectal (10%), and lung (7%). These cancers occur at lower rates in Hispanics than in non-Hispanic whites.However, Hispanics have higher rates for certain cancers, including cancers of the stomach, cervix, liver, and gallbladder, as well as acute lymphocytic leukemia. For example, stomach cancer incidence rates among Hispanic Americans are at least 70% higher than in non-Hispanic whites, possibly due to chronic infection with Helicobacter pylori (H. pylori), one of the strongest risk factors for the disease.
For many cancer types, Hispanics are far more likely than whites to be diagnosed in advanced stages of disease, when the cancer is likely to be less treatable. However, cancer survival rates are generally similar to non-Hispanic whites, except for melanoma, for which survival rates are lower compared to non-Hispanic white men (79% versus 87%) and women (88% versus 92%). That difference may reflect a later stage at diagnosis, among other things.
The researchers note these findings may mask important differences between Hispanic subpopulations. Because data in the US are reported for Hispanics as an aggregate group, it's difficult to draw out information for different subgroups – Mexicans as compared to Puerto Ricans, for example.
The report highlights the need for programs that target Hispanics, from addressing disparities in income, education, and access to health care to better understanding cultural values and beliefs.
"The Hispanic/Latino population will benefit from the same approaches that are most important in reducing cancer risk in the general population – preventing and treating tobacco dependence, increasing access to immunization programs, high quality cancer screening and appropriate follow-up care, increasing physical activity, and maintaining a healthy body weight,” said Vilma Cokkinides, Ph.D., American Cancer Society director for risk factor surveillance and one of the authors of this report. "In addition, many Hispanics face barriers to receiving adequate, affordable health care that likely have a significant impact on prevention, early detection, and treatment of cancer."

Childhood Cancer Awareness Month

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Did you know that this month is Childhood Cancer Awareness month? Kids all over the world are suffering from cancer. Hospital floors are filled with children with bald heads, going through chemotherapy, bone marrow transplants, and surgeries as they literally fight for their lives. Before 2007, I had no idea. I knew it existed of course, but I didn't really GET it. SO many children… I didn't get it until April 16, 2007 when childhood cancer became a very real part of our lives. Our then 2 year old daughter, Kennedy, was diagnosed with Acute Myelogenous Leukemia.
I will never forget the day they handed us this HUGE book to read about "understanding your child's cancer", or the first time I saw the poisonous chemotherapy drip through the IV lines into a tube in her chest. I'll never forget crying as I changed her sheets on her hospital bed because they were covered in her beautiful blonde hair…






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Rodolfo, Shy of small measurments

Erectile Dysfunction
 
Viagra
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Levitra
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